RELATIONSHIP OF LEVELS WITH CLINICAL PARAMETERS A MARKER OF NEUROAXONAL DAMAGE IN PARKINSON'S DISEASE AND ATYPIC PARKINSONISM SYNDROMES

Abstract

This study investigates the relationship between serum neurofilament light chain levels and clinical parameters in patients with Parkinson’s disease and Parkinsonism syndromes. The analysis included motor and cognitive functions, disease stage, and non-motor symptoms. Elevated neurofilament light chain levels were associated with more severe disease progression. Significant correlations were found with clinical scales such as UPDRS, MMSE, NMSS, and Hoehn & Yahr. These findings suggest that neurofilament light chain is a promising biomarker for early diagnosis, monitoring, and prognosis in clinical neurology.