THE ROLE OF METABOLIC CHANGES IN THE COURSE OF EPILEPSY, THE DEVELOPMENT OF COGNITIVE IMPAIRMENT, AND TREATMENT OPTIMIZATION IN ADOLESCENTS WITH EPILEPSY

Abstract

Epilepsy in adolescence is a complex neurological disorder characterized not only by recurrent seizures but also by cognitive, psycho-emotional, and metabolic disturbances. Adolescence is a critical developmental period involving functional maturation of the central nervous system, hormonal changes, intensive physica  growth, and rapid accumulation of bone mass. Therefore, both epilepsy itself and long-term antiseizure therapy may significantly affect energy metabolism, vitamin D status, bone metabolism, and cognitive functions.