Abstract
The article presents data on the initial neurological manifestations of
subacute sclerosing panencephalitis (SSPE) in children. SSPE is a rare progressive
degenerative disease of the central nervous system associated with persistent
measles virus infection. Clinical and anamnestic data of 11 children aged 3 to 8
years hospitalized in the pediatric neurology department of the multidisciplinary
clinic of Tashkent State Medical University were analyzed. It was found that most
patients had suffered measles at an early age. At the onset of the disease,
behavioral changes, cognitive impairment, speech disorders, and emotional
disturbances predominated, making early diagnosis difficult. It was noted that
parents often did not seek medical attention for a long time, considering these
symptoms as age-related behavioral characteristics. Serological methods, EEG,
and brain MRI were used to confirm the diagnosis. The study emphasizes the
importance of early detection of neurological manifestations of SSPE and the
necessity of laboratory verification for timely therapy and improvement of
patients’ quality of life.
