INTERRELATION OF KIMOKINE BIOMARKER LEVELS WITH CLINICAL PARAMETERS IN PARKINSON'S DISEASE AND PARKINSONISM “PLUS” SYNDROMES

Abstract

This article analyzes the relationship between monocyte-attracting chemical protein-1 (CCL2) levels and clinical indicators in Parkinson's disease and parkinsonism plus syndromes. Serum protein levels were compared with motor, cognitive, and stage changes. According to the study results, the level of this protein in parkinsonism plus syndromes was significantly higher and correlated significantly with Hoehn & Yahr, UPDRS, and MMSE indicators. These results indicate the possibility of using chemical protein-1, which attracts monocytes, as a useful biomarkers in differential diagnosis, prognosis, and assessment of the severity of the disease.